As loneliness, specifically in adolescents, is becoming more prevalent each year, the need to address and find interventions for the feeling of social or emotional deprivation is imperative. While previous studies have highlighted listening to music or singing in a choir as factors associated with the reduction of loneliness, addressing the physical act of playing an instrument, including the interconnectedness of motor responses and neuroplasticity when playing an instrument is vital. Therefore, this literature review synthesizes how the involvement of the brain and body when playing an instrument, in addition to how attending musical events may promote social bonding and synchrony in the context of loneliness reduction. This literature review concludes by arguing how playing an instrument and engaging in musical events may reduce loneliness. The physical act of playing an instrument, which engages sensorimotor skills, may promote neuroplasticity and neural network connection through the brain's dopaminergic reward system, synchrony, and peer-to-peer engagement in music contexts.