Autistic burnout is a debilitating state of chronic exhaustion, loss of previously acquired skills, and reduced tolerance to sensory and social demands that is widely reported by autistic adults, yet it remains poorly differentiated from co-occurring conditions such as depression and standard occupational burnout, and its neurobiological basis is largely uncharacterized. The objective of this scoping review was to map the existing evidence on the phenomenology, proposed neurobiological mechanisms, and interventional approaches associated with autistic burnout, and to identify where knowledge remains absent. Eligible sources concerned autistic individuals and the constructs of autistic burnout, camouflaging, emotion regulation, or autism-related neurobiology; occupational burnout was excluded. Following the framework of Arksey and O'Malley (2005) as refined by Levac et al. (2010), and reported in accordance with the PRISMA-ScR extension (Tricco et al., 2018), 34 sources were identified across multiple databases and charted by design, population, and thematic focus. The synthesis indicates that autistic burnout is consistently described as phenomenologically distinct from depression and standard burnout, that current neurobiological accounts are inferential rather than empirically established, and that no validated diagnostic criteria or condition-specific interventions yet exist. Three interlocking gaps were identified as the absence of a formally validated diagnostic construct, the lack of neurobiological studies conducted on autistic burnout itself, and the scarcity of longitudinal and interventional evidence. The paper also directs that establishing diagnostic clarity is a necessary precondition for the accurate identification and treatment of autistic adults affected by this condition.