Investigating the Effectiveness of Disease Models for Modelling of Alzheimer's in the Brain

This research undermines Alzheimer's disease (AD) and its issue on the global population. It examines the causes of AD through environmental factors, such as age and the molecular level, including improper protein folding, production and protein aggregation, through which analysis of different forms of disease modeling for AD arises. Various forms of disease models that were examined included mouse models, 2D models, organoid models, computational models and Brain on Chip models. The research examined and emphasized each model's benefits and disadvantages, and concluded that the Brain on Chip was more efficient in modeling AD. This is because it incorporates more variables, such as the blood-brain barrier, and several cellular mechanisms undermining the potential factor of initiating AD. This paper promotes the need for further studies and research on better modeling of AD.